Narcolepsy and the Hypocretin Receptor 2 Gene

Narcolepsy and the Hypocretin Receptor 2 Gene

hund narcoleptics. Similar analysis of cDNA from narco-leptic Labradors showed a 123 bp deletion of exon 6 and a G to A transition in the 5Ј splice junction consensus sequence. Thus, the genetic abnormality in Doberman Human narcolepsy, a chronic disorder that occurs in narcoleptics differs from that in Labrador narcoleptics, about 1 in 3000 individuals, is characterized by (1) exces-but both i...

Hypocretin/orexin, sleep and narcolepsy.

The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy and unusually rapid transitions to rapid-eye-movement sleep, opens a new field of investigation in the area of sleep control physiology. Hypocretin-1 and -2 (also called orexin-A and -B) are newly discovered neuropeptides processed from a common precursor, preprohypocret...

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and striking transitions from wakefulness into rapid eye movement (REM) sleep. In this study, we used positional cloning to identify an autosomal recessive mutation responsible for this sleep disorder in a well-established canine model. We have determined that canine narc...

Hypocretin Pathology in Human Narcolepsy

Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases

BACKGROUND A recent publication suggested molecular mimicry of a nucleoprotein (NP) sequence from A/Puerto Rico/8/1934 (PR8) strain, the backbone used in the construction of the reassortant strain X-179A that was used in Pandemrix® vaccine, and reported on anti-hypocretin (HCRT) receptor 2 (anti-HCRTR2) autoantibodies in narcolepsy, mostly in post Pandemrix® narcolepsy cases (17 of 20 sera). In...